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KMID : 0377519840090040479
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Chung-Ang Journal of Medicine
1984 Volume.9 No. 4 p.479 ~ p.489
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Immunohistochmical study on the Development of Pancreatic Islet in the Human Fetus
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Lee Won-Bok
Kim Dong-Chang
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Abstract
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The pancreases of Korean human fetuses aged from 13 to 40 weeks were studied immunohistochemically to observe the development of the pancreatic islet, frequency of single endocrine cell and composition of pancreatic islet. 1. The volume fractions of endocrine tissue of the fetal pancreas were higher value(from 7 to 8%). However, the relative values of the endocrine tissues that obtained from 5 to 10 month old fetuses were constant. 2. The exocrine tissue were slowly increased during the intrauterine life. On the other hand, the connective tissue were gradually decreased in the same time. 3. At the mid-term, the number of single alpha cells were similar to that of delta cells. The number of beta cell decreased in comparison with that of non-beta cells(p＜0.01). At the term, the number of single alpha, beta and delta cells were not significant. These data indicated that the epithelial cells of pancreatic duct were budding during intrauterine life. 4. At the mid-term, the pancreatic islets were composed of about 36% of alpha and beta cells respectively and 28% of delta cells. At the term the pancreatic were composed of 33% of alpha cells, 41% of beta cells and 26% of delta cells, respectively. The fetal panreatic islet showed numerous delta cells but the beta cells occupied one half of the adult islets. 5. The mantle islet was one of the typical features of fetal pancreatic islet. It was composed of the central core of beta cells and peripheral zone of alpha and delta cells interposed with a few of beta cells.
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